5.Same-day procedures appear to be a safe and reasonable option in the early second trimester, however, more research is needed to assess the effectiveness and safety of same-day procedures in the later second trimester.
PMID: 20687085 [PubMed - indexed for MEDLINE]
Gene therapy for sickle cell disease.
Lagos University Teaching Hospital, P.O.Box 8893 Marina, Lagos, Nigeria.
Abstract
BACKGROUND: Sickle cell disease encompasses a group of genetic disorders characterized by the presence of at least one hemoglobin S (Hb S) allele, and a second abnormal allele that could allow abnormal hemoglobin polymerisation leading to a symptomatic disorder.Autosomal recessive disorders (such as sickle cell disease) are good candidates for gene therapy because a normal phenotype can be restored in diseased cells with only a single normal copy of the mutant gene.
5.Same-day procedures appear to be a safe and reasonable option in the early second trimester, however, more research is needed to assess the effectiveness and safety of same-day procedures in the later second trimester.
回覆刪除PMID: 20687085 [PubMed - indexed for MEDLINE]
5.在第二學期的剛開始，同一天的程序似乎是一個較安全、合理的選擇，然而，在第二學期的結尾，需要做更多研究評估同一天程序的效果和安全。
Gene therapy for sickle cell disease.
對於鐮刀型細胞的基因治療法
Olowoyeye A, Okwundu CI.
歐羅萵A, 歐可文杜 CI
Lagos University Teaching Hospital, P.O.Box 8893 Marina, Lagos, Nigeria.
拉哥斯(奈及利亞的首都)大學教學醫院, 奈及利亞拉哥斯的小艇碼頭郵局信箱8893號
Abstract摘要
BACKGROUND: Sickle cell disease encompasses a group of genetic disorders characterized by the presence of at least one hemoglobin S (Hb S) allele, and a second abnormal allele that could allow abnormal hemoglobin polymerisation leading to a symptomatic disorder.Autosomal recessive disorders (such as sickle cell disease) are good candidates for gene therapy because a normal phenotype can be restored in diseased cells with only a single normal copy of the mutant gene.
背景：
鐮刀型細胞疾病包含一組具有至少一個血紅素(血色素)對偶基因存在特徵的基因混亂，而且第二個不正常的對偶基因會讓不正常的血紅素聚合作用而導致混亂的症狀，因為一個正常顯型細胞可以藉著只有一個單獨、正常的突變基因複製品的不健全細胞得以恢復。
5.在第二期的剛開始，同一天的程序似乎是一個較安全、合理的選擇，然而，在第二期的結尾，需要做更多研究評估同一天程序的效果和安全。
回覆刪除對於鐮刀型細胞的基因治療法
Lagos University Teaching Hospital, P.O.Box 8893 Marina, Lagos, Nigeria.
拉哥斯(奈及利亞的首都)大學教學醫院, 奈及利亞拉哥斯的小艇碼頭郵局信箱8893號
Abstract摘要
背景：
鐮刀型細胞疾病包含一組具有至少一個血紅素(血色素)對偶基因存在特徵的混亂基因，而且第二個不正常的對偶基因會讓不正常的血紅素聚合作用而導致混亂的症狀，因為一個正常顯型細胞可以藉著只有一個單獨、正常的突變基因複製品的不健全細胞得以恢復。